I would assume you could. But Il2 is not arcady like War Thunder. It would be much better experience with a joystick. Even a cheap Logitech one would do. You really have to pay attention when flying especially during take off and landing. Not sure how that would go with mouse and keyboard as you have other things you have to deal with as well. Flaps, Trim, RPM, Throttle. With a joystick you map a lot of those functions to joystick buttons/hats.